Synthesis of selenocystine and selenohomocystine with O-acetylhomoserine sulfhydrylase

P Chocat, N Esaki, H Tanaka…

文献索引：Chocat, Patrick; Esaki, Nobuyoshi; Tanaka, Hidehiko; Soda, Kenji Agricultural and Biological Chemistry, 1985 , vol. 49, # 4 p. 1143 - 1150

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被引用次数: 26

摘要

We describe here the synthesis of selenium amino acids with O-acetylhomoserine sulfhydrylase, partially purified from baker's yeast. The enzyme was found to catalyze the synthesis of l-selenocystine and l-selenohomocystine from Na2Se2 with the corresponding acetyl-derivatives of serine and homoserine, respectively. l-Serine-O-sulfate also serves as a substrate of the β-replacement reaction. Na2Se2 is less efficient as a substituent donor ...