Versatile synthesis of quaternary 1, 3-oxazolidine-2, 4-diones and their use in the preparation of α-hydroxyamides

…, HA Jiménez-Vázquez, LG Zepeda, J Tamariz

文献索引：Merino, Omar; Santoyo, Blanca M.; Montiel, Luisa E.; Jimenez-Vazquez, Hugo A.; Zepeda, L. Gerardo; Tamariz, Joaquin Tetrahedron Letters, 2010 , vol. 51, # 29 p. 3738 - 3742

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被引用次数: 13

摘要

A new approach to the synthesis of 1, 3-oxazolidine-2, 4-diones, via a two-step reaction sequence, starting from the readily available α-ketols and isocyanates, is reported. The condensation of the latter led to the key precursors 4-methylene-2-oxazolidinones, which are converted into the diones by an oxidative cleavage of the exocyclic double bond. Thus, 5, 5-disubstituted 1, 3-oxazolidine-2, 4-diones can be accessed in good yields from the ...