Tetrahedron Letters

Magnesium/methanol: an effective reducing agent for chemoselective reduction of pyrimidine-2 (1H)-ones

K Singh, K Singh

文献索引：Singh, Kamaljit; Singh, Kawaljit Tetrahedron Letters, 2009 , vol. 50, # 19 p. 2219 - 2221

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被引用次数: 7

摘要

Magnesium in methanol is an effective reagent for the chemoselective reduction of pyrimidine-2 (1H)-ones. Other reducible functionalities such as ester and alkene of enamine ester and uriedo carbonyl remain unaffected. This constitutes the first example of the formation of Biginelli 3, 4-dihydropyrimidin-2 (1H) ones through the reduction of pyrimidine-2 (1H)-ones.