Abstract A series of novel substituted 3, 6-disubstituted pyridazines based on the structure of vatalanib (PTK787) were designed and synthesized. The cytotoxicity of the final compounds was tested in vitro on HT-29 colon cancer cell line. Compounds 2a and 2b with 4- chlorophenylamino moiety, exerted the highest cytotoxic activity with IC 50 values equal to 15.3 and 3.9 μM respectively. The most promising compound, 2b, was found to be about ...
