Asymmetric syntheses via heterocyclic intermediates, XXXI. Asymmetric synthesis of various non??proteinogenic amino acid methyl esters (functionalized in the carbon …

U Schoellkopf, U Busse, R Lonsky…

文献索引：Schoellkopf, Ulrich; Busse, Ulrich; Lonsky, Ralph; Hinrichs, Rolf Liebigs Annalen der Chemie, 1986 , # 12 p. 2150 - 2163

全文：HTML全文

被引用次数: 15

摘要

Abstract The lithiated bislactim ethers 5, 10, 12, and 23 were alkylated with a variety of alkylating agents 6 to give the alkylated bislactim ethers 7, 11, 13, and 24 with a high degree of asymmetric induction (up to 99%). Upon hydrolysis these furnished the optically active amino acid methyl esters of type 8, 14, or 25. Some of these amino acid esters were further hydrolyzed to yield the amino acids.