Synthesis and pharmacological screening of derivatives of isoxazolo [4, 3??d] pyrimidine and isoxazolo [4, 5??d] pyrimidine

…, L Becan, W Sawka??Dobrowolska

文献索引：Wagner, Edwin; Al-Kadasi, Kamal; Becan, Lilianna; Sawka-Dobrowolska, Wanda Journal of Heterocyclic Chemistry, 2010 , vol. 47, # 3 p. 677 - 682

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被引用次数: 6

摘要

The bases of the 9H-purines adenosine (adenine) and the adenosine metabolite inosine (hypoxantine) are endogenous ligands of different receptors. Adenosine is an endogenous ligand of adenosine receptors (AR). They are subdivided into four subtypes (A1, A2A, A2B, and A3)[1]. Adenosine receptors have been actively studied as potential therapeutic targets in several disorders, such as Parkinson's disease, schizophrenia, analgesia, and ...