Structural Insight into the Unique Binding Properties of Pyridylethanol (phenylethyl) amine Inhibitor in Human CYP51

…, D Rozman, S Golič Grdadolnik

文献索引：Korosec, Tina; Grdadolnik, Joze; Urleb, Uros; Kocjan, Darko; Grdadolnik, Simona Golic Journal of Organic Chemistry, 2006 , vol. 71, # 2 p. 792 - 795

全文：HTML全文

被引用次数: 0

摘要

Sterol 14α-demethylase (CYP51) is the main drug target for the treatment of fungal infections. The discovery of new efficient fungal CYP51 inhibitors requires an understanding of the structural requirements for selectivity for the fungal over the human ortholog. In this