Chemical and Pharmaceutical Bulletin

Formal (3+ 3) Cycloaddition of Silyl Enol Ethers Catalyzed by Trifric Imide: Domino Michael Addition-Claisen Condensation Accompanied with Isomerization of Silyl …

T Azuma, Y Takemoto, K Takasu

文献索引：Azuma, Takumi; Takemoto, Yoshiji; Takasu, Kiyosei Chemical and Pharmaceutical Bulletin, 2011 , vol. 59, # 9 p. 1190 - 1193

全文：HTML全文

被引用次数: 7

摘要

We describe here a Tf 2 NH-catalyzed formal (3+ 3) cycloaddition of silyl enol ethers with acrylates as a new domino reaction. In the domino sequence, the catalyst activates Michael addition, deprotonation of the resulting silyloxonium cation and intramolecular Claisen condensation. It was found that reaction modes significantly depend on the reaction temperature. We also examined the mechanistic detail of the reaction by 1 H-NMR ...