Design and Synthesis of 3??Aryl??5??Alicylic??[1, 2, 4]??oxadiazoles as Novel Platelet Aggregation Inhibitors

CY Chern, SJ Chen, WM Kan

文献索引：Chern, Ching-Yuh; Chen, Shinn-Jyh; Kan, Wai-Ming Journal of the Chinese Chemical Society, 2005 , vol. 52, # 2 p. 331 - 338

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被引用次数: 1

摘要

Abstract A series of 4-[2-(alicyclic-[1, 2, 4] oxadiazol-3-yl) phenoxy]-butyric acids were synthesized from N-hydroxy-2-isopropoxy benzamidine in 4 steps with good yields. These [1, 2, 4] oxadiazoles are novel platelet aggregation inhibitors preventing human platelet aggregation induced by thromboxane derivative U44, 619 and adenosine diphosphate. A structure-activity-relationship study revealed that the potency for these 5-oxadiazoles ...