5-HT 3 R Binding of lerisetron: an interdisciplinary approach to drug–Receptor interactions

…, P Venkataraman, MK Schulte, KS Kirschbaum

文献索引：Parihar, Harish S.; Suryanarayanan, Asha; Ma, Chun; Joshi, Prasad; Venkataraman, Padma; Schulte, Marvin K.; Kirschbaum, Karen S. Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 16 p. 2133 - 2136

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被引用次数: 14

摘要

The design, synthesis, and use of lerisetron-based molecular probes to investigate the 5- HT3R binding site are described. A SAR study, which involved distance and electronic parameter modifications of lerisetron's N-benzyl group, resulted in the discovery of a partial agonist.