Tetrahedron letters

Enantioselective allylation of α-ketoester oximes with an external chiral ligand: Asymmetric synthesis of allylglycines and allylalanine

S Hanessian, RY Yang

文献索引：Hanessian, Stephen; Yang, Rui-Yang Tetrahedron Letters, 1996 , vol. 37, # 50 p. 8997 - 9000

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被引用次数: 61

摘要

A highly enantioselective allylation of oximes of α-ketoesters is described with phenyl substituted chiral bis (oxazoline) as external ligand of allylzinc reagents. This method provides an efficient and convenient access to N-benzyloxy allylglycine, allylglycine and chain substituted variants with high enantiomeric purities.