Tetrahedron

Regioselective aluminium chloride induced heteroarylation of pyrrolo [1, 2-b] pyridazines: its scope and application

M Pal, VR Batchu, S Khanna, KR Yeleswarapu

文献索引：Pal, Manojit; Batchu, Venkateswara Rao; Khanna, Smriti; Yeleswarapu, Koteswar Rao Tetrahedron, 2002 , vol. 58, # 50 p. 9933 - 9940

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被引用次数: 32

摘要

We describe a detailed study on the novel synthesis of 6, 7-disubstituted pyrrolo [1, 2-b] pyridazines through AlCl3 induced C–C bond formation reactions. A wide variety of 6-aryl substituted azolopyridazines was reacted with 3, 6-dichloropyridazine to give 7-pyridazinyl substituted pyrrolopyridazines regioselectively in good to excellent yield. The mechanism and regiochemistry of the reaction along with applications of the methodology are ...