Heterocycles

The synthesis of N-{2-amino-4-substituted [(pyrrolo [2, 3-d] pyrimidin-5-yl) ethyl] benzoyl}-L-glutamic acids as antineoplastic agents

C SHIH, LS Gossett

文献索引：Shih, Chuan; Gossett, L. S. Heterocycles, 1993 , vol. 35, # 2 p. 825 - 841

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被引用次数: 17

摘要

Résumé/Abstract A series of N-{2-amino-4-substituted [(pyrrolo [2, 3-d] pyrimidin-5-yl) ethyl] benzoyl}-L-glutamic acids were synthesized. In this current synthesis, compound 2-amino-4- chloro-pyrrolo [2, 3-d] pyrimidine (4) was selected as an important precursor for the preparation of key intermediates such as 5b, 10b, 15a and 15b. These highly functionalized pyrrolo [2, 3-d] pyrimidines were then later coupled with either 4-ethynylbenzoylglutamate ...