Glycogen phosphorylase inhibitory effects of 2-oxo-1, 2-dihydropyridin-3-yl amide derivatives

ND Karis, WA Loughlin, ID Jenkins, PC Healy

文献索引：Karis, N. David; Loughlin, Wendy A.; Jenkins, Ian D.; Healy, Peter C. Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 13 p. 4724 - 4733

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被引用次数: 6

摘要

Glycogen phosphorylase (GP) plays a crucial role in the conversion of glycogen to glucose- 1-phosphate (and in turn glucose) and is a promising target for therapeutic intervention in diabetes. In this study we synthesized new derivatives of 2-oxo-1, 2-dihydropyridin-3-yl amides using a facile aminolysis reaction, in which different alkyl and aryl esters and amides are substituted at N-1 and C-3 of the heterocyclic ring. The in vitro inhibitory activity of ...