1, 3-vs 1, 5-intramolecular alkylation reactions in isophosphoramide and phosphoramide mustards
…, KI Koo, OM Colvin, ME Colvin, ME Dolan…
文献索引：Balu, Narayanan; Gamcsik, Michael P.; Colvin, Michael E.; Colvin, O. Michael; Dolan, M. Eileen; Ludeman, Susan M. Chemical Research in Toxicology, 2002 , vol. 15, # 3 p. 380 - 387
It is well-established that at pH 7.4, intramolecular 1, 3-N-alkylation reactions in isophosphoramide mustard (IPM) and phosphoramide mustard (PM) produce electrophilic alkylating agents with aziridinyl moieties. To investigate the role of 1, 5-intramolecular cyclizations in the chemistry of IPM and PM, the five-membered ring phospholidine products of these reactions were independently synthesized and characterized by 31P NMR. In ...
