Asymmetric Synthesis of Maraviroc (UK??427,857)

GL Zhao, S Lin, A Korotvička, L Deiana…

文献索引：Zhao, Gui-Ling; Lin, Shuangzheng; Korotvicka, Ales; Deiana, Luca; Kullberg, Martin; Cordova, Armando Advanced Synthesis and Catalysis, 2010 , vol. 352, # 13 p. 2291 - 2298

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被引用次数: 20

摘要

Abstract The asymmetric synthesis of Maraviroc (UK-427,857), a chemochine receptor 5 (CCR-5) receptor antagonist, based on an expeditious organocatalytic enantioselective assembly of the chiral β-amino aldehyde key fragment is presented. The reactions were performed on a gram-scale and allow for the rapid construction of new Maraviroc analogues.