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Journal of the American Chemical Society

Azatides: Solution and liquid phase syntheses of a new peptidomimetic

H Han, KD Janda

文献索引:Han; Janda Journal of the American Chemical Society, 1996 , vol. 118, # 11 p. 2539 - 2544

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被引用次数: 182

摘要

An efficient method has been developed for the solution and liquid phase syntheses of a biopolymer mimetic consisting of “α-aza-amino acids” linked in a repetitive manner to form what we term an azatide oligomer. To construct this biopolymer mimetic, three stages of research were pursued as follows:(1) development of general synthetic procedures that allowed the synthesis of a wide variety of Boc-protected aza-amino acid monomers,(2) ...