Bioorganic & medicinal chemistry letters

Design, synthesis and antimuscarinic activity of some imidazolium derivatives

H Miyachi, H Kiyota, M Segawa

文献索引：Miyachi, Hiroyuki; Kiyota, Hiromi; Segawa, Mitsuru Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 20 p. 3003 - 3008

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被引用次数: 28

摘要

A series of imidazolium salt derivatives was prepared as part of a search for subtype- selective antimuscarinic agents. On the basis of measurements of the antimuscarinic activity and subtype-selectivity for M2 and M3 muscarinic receptors, the structure-activity relationships of these compounds are discussed.