New Journal of Chemistry

The enantioselective hydrogenation of 5, 6-dihydro-2H-pyran-3-carboxylic acid over a cinchona alkaloid-modified palladium catalyst: asymmetric synthesis of a …

K Szőri, G Szőllősi, M Bartók

文献索引：Szori, Kornel; Szollosi, Gyoergy; Bartok, Mihaly New Journal of Chemistry, 2008 , vol. 32, # 8 p. 1354 - 1358

全文：HTML全文

被引用次数: 10

摘要

A novel application of a cinchona-modified supported Pd catalyst is presented. The key step in the asymmetric synthesis of the cockroach attractant methyl (+)-tetrahydro-2H-pyran-3- carboxylate was the enantioselective hydrogenation of 5, 6-dihydro-2H-pyran-3-carboxylic acid over 5% Pd/Al2O3 modified by cinchonidine, which afforded the saturated product in up to 89% optical purity.