Steroids

Facile radiosynthesis of new carbon-11-labeled propanamide derivatives as selective androgen receptor modulator (SARM) radioligands for prostate cancer imaging

M Gao, M Wang, KD Miller, QH Zheng

文献索引：Gao, Mingzhang; Wang, Min; Miller, Kathy D.; Zheng, Qi-Huang Steroids, 2011 , vol. 76, # 13 p. 1505 - 1512

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被引用次数: 3

摘要

The androgen receptor (AR) is an attractive target for the treatment and molecular imaging of prostate cancer. New carbon-11-labeled propanamide derivatives were first designed and synthesized as selective androgen receptor modulator (SARM) radioligands for prostate cancer imaging using the biomedical imaging technique positron emission tomography (PET). The target tracers,(S)-N-(4-cyano-3-(trifluoromethyl) phenyl)-2-hydroxy-3-(2-[11C] ...