Synthesis, and Cytotoxic Activity of Nind-Alkoxy Derivatives of Antibiotic Arcyriarubin and Dechloro-rebeccamycin Aglycon.

…, J Balzarini, G Andrei, R Snoeck, EDE CLERCQ…

文献索引：Lakatosh; Balzarini; Andrei; Snoeck; De Clercq; Preobrazhenskaya Journal of Antibiotics, 2002 , vol. 55, # 8 p. 768 - 773

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被引用次数: 14

摘要

EtOAc). HR-MS calcd for C22H15N3O3 M+ 369.1113, found 369.1077). Under more drastic conditions (MeI, NaH, DMF) N, N, O-trimethyl derivative 10 was obtained (Scheme 2). Formation of 10 was also observed by TLC when the reaction done under milder conditions (MeI, acetone, K2CO3) was allowed to stir overnight [10, a brown foam, Rf 0.22 (n-heptane- EtOAc, 10: 1). HR-MS calcd for