Nitrosoimidazoles: Highly bactericidal analogs of 5-nitroimidazole drugs

…, BB Beaulieu Jr, P Goldman

文献索引：Ehlhardt, William J.; Beaulieu, Bernard B.; Goldman, Peter Journal of Medicinal Chemistry, 1988 , vol. 31, # 2 p. 323 - 329

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被引用次数: 34

摘要

It is believed that metronidazole and related 5-nitroimidazoles are activated by reduction of the nitro group and that the active species has a nitrogen functionality of intermediate oxidation state. However, the preparation and isolation of the active forms of the 5- nitroimidazoles used therapeutically have proven elusive. To pursue this problem we have prepared both l-methyl-4-phenyl-5-nitrosoimidazole (3) and l-methyl-4-nitroso-5- ...