Initial efforts toward the optimization of arylomycins for antibiotic activity

…, J Liu, PA Smith, FE Romesberg

文献索引：Roberts, Tucker C.; Smith, Peter A.; Cirz, Ryan T.; Romesberg, Floyd E. Journal of the American Chemical Society, 2007 , vol. 129, # 51 p. 15830 - 15838

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被引用次数: 26

摘要

While most clinically used antibiotics were derived from natural products, the isolation of new broad-spectrum natural products has become increasingly rare and narrow-spectrum agents are typically deemed unsuitable for development because of intrinsic limitations of their scaffold or target. However, it is possible that the spectrum of a natural product antibiotic might be limited by specific resistance mechanisms in some bacteria, such as ...