A scalable process for the synthesis of the bcl inhibitor obatoclax

K Daïri, Y Yao, M Faley, S Tripathy…

文献索引：Organic Process Research and Development, , vol. 11, # 6 p. 1051 - 1054

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被引用次数: 22

摘要

... Organic Process Research & Development. ... decomposition of the boronic acid 6 under heating (by loss of the boronic acid group) were competitive processes, but a ... This three-step process was recently applied to the production of 1.5 kg of obatoclax to support clinical studies ...