Tetrahedron Letters

The synthesis of substituted (4S)-4-(hydroxymethyl) imidazolidin-2-ones as novel protein kinase C modulators

L Zhao, L Qiao, SB Rong, AP Kozikowski

文献索引：Zhao; Qiao; Rong; Kozikowski Tetrahedron Letters, 2000 , vol. 41, # 45 p. 8711 - 8715

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被引用次数: 7

摘要

The total synthesis of substituted (4S)-4-(hydroxymethyl) imidazolidin-2-ones from D-serine methyl ester is described. The key step in the synthesis is a reductive amination reaction which is brought about using titanium (IV) isopropoxide and sodium cyanoborohydride, followed by the cyclization to urea using triphosgene after deprotection.