A convergent synthetic methodology has been developed to access both (2 S)-and (2 R)-3- fluoroalanine and their corresponding N-methyl analogues, in optically pure form, through a common oxazolidinone intermediate that can be obtained from l-or d-serine. In addition, a procedure for incorporation of these unnatural amino acids in peptide scaffolds is also disclosed herein that minimizes the occurrence of β-elimination during amide bond ...
