Synthesis and antiviral activity of an imidazo [1, 2-a] pyrrolo [2, 3-c] pyridine series against the bovine viral diarrhea virus

JM Chezal, J Paeshuyse, V Gaumet, D Canitrot…

文献索引：Chezal, Jean-Michel; Paeshuyse, Jan; Gaumet, Vincent; Canitrot, Damien; Maisonial, Aurelie; Lartigue, Claire; Gueiffier, Alain; Moreau, Emmanuel; Teulade, Jean-Claude; Chavignon, Olivier; Neyts, Johan European Journal of Medicinal Chemistry, 2010 , vol. 45, # 5 p. 2044 - 2047

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被引用次数: 34

摘要

A series of imidazo [1, 2-a] pyrrolo [2, 3-c] pyridines has been prepared and evaluated for their anti-BVDV activities in MDBK cells. From the synthesized analogues bearing modifications of the substituents at positions 2, 3, 7 and 8, compounds 10a, b, 16, 24, 25 and 26 exhibited significant anti-BVDV activities.