2, 5-Dimethoxy congeners of (+)-and (-)-3-(3-hydroxyphenyl)-Nn-propylpiperidine

…, KS Kirschbaum, VED Amoo, AK Johnson…

文献索引：Cannon; Kirschbaum; Amoo; Johnson; Long Journal of Medicinal Chemistry, 1993 , vol. 36, # 16 p. 2416 - 2419

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被引用次数: 5

摘要

and at high doses it also exhibits postsynaptic antagonism.(R)-1 is a postsynaptic agonist. In a continuation of studies of effects of the p-dimethoxy moiety at dopamine receptors, synthesis and resolution of the 2, 5-dimethoxy analog 3 of 3-PPP was undertaken. The two enantiomers and the racemic modification showed cardiovascular effects consistent with actions at DA-2 receptors. The potency of all three compounds was much lower than that ...