Discovery of highly selective EP4 receptor agonists that stimulate new bone formation and restore bone mass in ovariectomized rats

KO Cameron, BA Lefker, MY Chu-Moyer…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 7 p. 1799 - 1802

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被引用次数: 32

摘要

... Bioorganic & Medicinal Chemistry Letters. ... Chemical modification led to compound 16c, which was about 30× more potent in vivo. ... C. Hansch, PG Sammes, JB Taylor, JC Emmett (Eds.), Comprehensive Medicinal Chemistry, Vol. 3Pergamon, Oxford (1989), pp. 643–714. ...