Lack of effect of the length of oligoglycine-and oligo (ethylene glycol)-derived para-substituents on the affinity of benzenesulfonamides for carbonic anhydrase II in …

A Jain, SG Huang, GM Whitesides

文献索引：Jain, Ahamindra; Huang, Shaw G.; Whitesides, George M. Journal of the American Chemical Society, 1994 , vol. 116, # 12 p. 5057 - 5062

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被引用次数: 68

摘要

Abstract: Using IH NMR spectroscopy, values of Tz have been determined for the methylene protons of the oligoglycine moieties of para-substituted benzenesulfonamides having structures H2NO2SC6H4CO (Gly),, OH (n= 1-6) bound at the active site of bovine carbonic anhydrase I1 (CA, EC 4.2. 1.1). These values have been correlated with measurements of dissociation constants of these complexes, in order to infer motion of these ligands when ...