Tetrahedron: Asymmetry

Chemoenzymatic preparation of optically active secondary amines: a new efficient route to enantiomerically pure indolines

V Gotor-Fernández, P Fernández-Torres…

文献索引：Gotor-Fernandez, Vicente; Fernandez-Torres, Pedro; Gotor, Vicente Tetrahedron Asymmetry, 2006 , vol. 17, # 17 p. 2558 - 2564

全文：HTML全文

被引用次数: 42

摘要

An efficient chemoenzymatic route for the synthesis of optically active substituted indolines has been developed. Different lipases have been tested in the alkoxycarbonylation of these secondary amines, Candida antarctica lipase A (CAL-A) was found to be the best biocatalyst for 2-substituted-indolines, and C. antarctica lipase B (CAL-B) for 3-methylindoline. The combination of lipases with a variety of allyl carbonates and tert-butyl methyl ether (TBME) ...