Tetrahedron

An efficient synthesis of some 6-substituted 4, 8-diaza-3, 3, 9, 9-tetramethylundeca-2, 10-dione dioximes (propylene amine oximes, PnAOs): Ligands for 99m Tc …

P Nanjappan, N Raju, K Ramalingam, DP Nowotnik

文献索引：Nanjappan, Palaniappa; Raju, Natarajan; Ramalingam, Kondareddiar; Nowotnik, David P. Tetrahedron, 1994 , vol. 50, # 29 p. 8617 - 8632

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被引用次数: 12

摘要

Technetium complexes of the ligand PnAO [4, 8-diaza-3, 3, 9, 9-tetramethylundeca-2, 10- dione dioximes (3)] are of interest as commercial radiopharmaceuticals. In general, PnAOs are synthesized by alkylation of a propylenediamine derivative with 3-chloro-3-methyl-2- nitrosobutane (2). This alkylation reaction proved to be low yielding. With modestly bulky substituents at the 2-position of 1, 3-diaminopropane, little or none of the required PnAO ...