Abstract An eight-step synthesis of a new water-soluble tripodal ligand TRENPYPOLS (tris [2- (2-hydroxy-3-(2-pyridinyl)-5-sulfobenzamido) ethyl] amine) is described. TRENPYPOLS is built by connecting the TREN spacer through a tris-amide moiety to the ortho phenolic position of three 2-(2-hydroxyphenyl) pyridine chelating subunits,(followed by the sulfonation of the 5-positions). The three [O, N pyr] bidentate subunits of TRENPYPOLS ...