Synthesis and initial evaluation for in vivo chelation of Pu (IV) of a mixed octadentate spermine-based ligand containing 4-carbamoyl-3-hydroxy-1-methyl-2 (1 H)- …
J Xu, PW Durbin, B Kullgren, SN Ebbe…
文献索引：Xu, Jide; Durbin, Patricia W.; Kullgren, Birgitta; Ebbe, Shirley N.; Uhlir, Linda C.; Raymond, Kenneth N. Journal of Medicinal Chemistry, 2002 , vol. 45, # 18 p. 3963 - 3971
An improved synthesis for a series of 1-hydroxy-2 (1 H)-pyridinone-based octadentate ligands is reported. The mixed chelate, octadentate ligand, 3, 4, 3-LI (1, 2-Me-3, 2-HOPO), was designed, synthesized, and tested for in vivo chelation of Pu in a mouse model. This ligand incorporates both 1, 2-HOPO and Me-3, 2-HOPO metal chelating units; the latter has higher affinity toward actinide ions than does 1, 2-HOPO at physiological pH. Injected or ...
