Total synthesis and cytoprotective properties of dykellic acid

…, CA Quinn, PJ Hergenrother

文献索引：Thompson, Christina M.; Quinn, Catherine A.; Hergenrother, Paul J. Journal of Medicinal Chemistry, 2009 , vol. 52, # 1 p. 117 - 125

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被引用次数: 12

摘要

Small molecule inhibitors of apoptosis hold considerable promise for the treatment of a host of diseases, including neurodegeneration, myocardial infarction, and stroke. Many compounds that delay or prevent apoptotic death either reduce the amount of cellular reactive oxygen species (ROS) or are direct inhibitors of caspases. With the goal of using small molecules to identify novel antiapoptotic targets, we have investigated the ...