Journal of medicinal chemistry

4-Anilidopiperidine analgesics. 3. 1-Substituted 4-(propananilido) perhydroazepines as ring-expanded analogs

ZG Finney, TN Riley

文献索引：Finney, Z. Gail; Riley, Thomas N. Journal of Medicinal Chemistry, 1980 , vol. 23, # 8 p. 895 - 899

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被引用次数: 30

摘要

A study of ring-expanded analogues of the 4-(propanani1ido) piperidine analgesics has been undertaken in order to evaluate the influence of this structural modification on both analgesic activity and physical-dependence capacity. Thus, a series of 1-substituted 4- (propanani1ido) perhydroazepine derivatives was synthesized and pharmacologically evaluated in mice for analgesic activity and physical-dependence capacity. The results of ...