Enantioselective synthesis of chiral α-aryl or α-alkyl substituted ethylphosphonates via Rh-catalyzed asymmetric hydrogenation with a P-stereogenic BoPhoz-type …

…, J Deng, SB Yu, ZC Duan, Z Zheng

文献索引：Huang, Jia-Di; Hu, Xiang-Ping; Duan, Zheng-Chao; Zeng, Qing-Hen; Yu, Sai-Bo; Deng, Jun; Wang, Dao-Yong; Zheng, Zhuo Organic Letters, 2006 , vol. 8, # 19 p. 4367 - 4370

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被引用次数: 35

摘要

An enantioselective synthesis of optically active 1-aryl or 1-alkyl substituted ethylphosphonates, based on the first Rh-catalyzed asymmetric hydrogenation of corresponding α, β-unsaturated precursors with a P-stereogenic BoPhoz-type ligand under the mild condition, was developed, in which a wide range of 1-aryl or 1-alkyl substituted ethylphosphonates were achieved in up to 98% ee.