TiCl 4-mediated olefination of aldehydes with acetic acid and alkyl acetates: a stereoselective approach to (E)-α, β-unsaturated carboxylic acids and esters

…, C Boodappa, S Venkatachaliah, A Mariappan

文献索引：Augustine, John Kallikat; Boodappa, Chandrakantha; Venkatachaliah, Srinivasa; Mariappan, Ayyampillai Tetrahedron Letters, 2014 , vol. 55, # 24 p. 3503 - 3506

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被引用次数: 3

摘要

Abstract A new method has been developed for the preparation of α, β-unsaturated carboxylic acids and corresponding esters with (E)-stereoselectivity via the TiCl 4-mediated olefination of aldehydes. The method, which uses readily available acetic acid or its alkyl esters as active methylene partners, is more flexible and complementary to conventional routes in the preparation of (E)-cinnamic acid derivatives.