N-acetylgalactosamino dendrons as clearing agents to enhance liver targeting of model antibody-fusion protein

…, J Pu, B Punzalan, SM Larson, O Ouerfelli

文献索引：Yoo, Barney; Cheal, Sarah M.; Torchon, Geralda; Dilhas, Anna; Yang, Guangbin; Pu, Jun; Punzalan, Blesida; Larson, Steven M.; Ouerfelli, Ouathek Bioconjugate Chemistry, 2013 , vol. 24, # 12 p. 2088 - 2103

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被引用次数: 2

摘要

Dendrimer clearing agents represent a unique class of compounds for use in multistep targeting (MST) in radioimmunotherapy and imaging. These compounds were developed to facilitate the removal of excess tumor-targeting monoclonal antibody (mAb) prior to administration of the radionuclide to minimize exposure of normal tissue to radiation. Clearing agents are designed to capture the circulating mAb, and target it to the liver for ...