Synthesis and evaluation of bifunctional chelating agents derived from bis (2-aminophenylthio) alkane for radioimaging with 99m Tc

BS Chhikara, N Kumar, V Tandon, AK Mishra

文献索引：Chhikara, Bhupender S.; Kumar, Nitin; Tandon, Vibha; Mishra, Anil K. Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 15 p. 4713 - 4720

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被引用次数: 17

摘要

Novel bifunctional chelating agents bearing an aromatic rigid backbone have been synthesized and characterized on the basis of spectroscopic techniques. These macrocyclic multidentate chelating agents were conjugated with monoclonal antibody which forms stable complexes with 99mTc with high radiochemical purity.