In vitro and in vivo anti-Leishmania activity of polysubstituted synthetic chalcones

…, D Castillo, Y Estevez, G Gonzalez, J Arevalo…

文献索引：Aponte, Jose C.; Castillo, Denis; Estevez, Yannick; Gonzalez, German; Arevalo, Jorge; Hammond, Gerald B.; Sauvain, Michel Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 1 p. 100 - 103

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被引用次数: 37

摘要

The in vitro screening of 43 polysubstituted chalcones against Leishmania amazonensis axenic amastigotes, led to the evaluation of 9 of them in a macrophage-infected model with the two other most infectious Leishmania species prevalent in Peru (L. braziliensis and L. peruviana). The five most active and selective chalcones were studied in vivo, resulting on the identification of two chalcones with high reduction parasite burden percentages.