Synthesis of amide compounds of ferulic acid, and their stimulatory effects on insulin secretion in vitro

…, K Nakamura, H Morishita, T Tsuno, H Taniguchi

文献索引：Nomura, Eisaku; Kashiwada, Ayumi; Hosoda, Asao; Nakamura, Kozo; Morishita, Hideko; Tsuno, Takuo; Taniguchi, Hisaji Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 17 p. 3807 - 3813

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被引用次数: 74

摘要

We prepared amide compounds which were derived from ferulic acid using various amines, and investigated their stimulatory effects on insulin secretion using rat pancreatic RIN-5F cells. Most of these compounds exhibited significant promotion of the insulin-release at a concentration of 10 μM and in particular, the amides having n-butyl, n-pentyl, pyrrolidine, and piperidine groups showed high activity.