Acyclic analogues of adenosine bisphosphates as P2Y receptor antagonists: phosphate substitution leads to multiple pathways of inhibition of platelet aggregation

…, G Kirschenheuter, AF Greslin, X Cheng…

文献索引：Xu, Bin; Stephens, Andrew; Kirschenheuter, Gary; Greslin, Arthur F.; Cheng, Xiaoquin; Sennelo, Joe; Cattaneo, Marco; Zighetti, Maddalena L.; Chen, Aishe; Kim, Soon-Ai; Kim, Hak Sung; Bischofberger, Norbert; Cook, Gary; Jacobson, Kenneth A. Journal of Medicinal Chemistry, 2002 , vol. 45, # 26 p. 5694 - 5709

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被引用次数: 80

摘要

Activation by ADP of both P2Y1 and P2Y12 receptors in platelets contributes to platelet aggregation, and antagonists at these receptor subtypes have antithrombotic properties. In an earlier publication, we have characterized the SAR as P2Y1 receptor antagonists of acyclic analogues of adenine nucleotides, containing two phosphate groups on a symmetrically branched aliphatic chain, attached at the 9-position of adenine. In this study, ...