Phosphorus, Sulfur, and Silicon

Synthesis and Biological Activity of 2-Hydroxy-N (5-methylene-4-oxo-2-aryl-thiazolidin-3-yl)-benzamide

HS Patel, SJ Patel

文献索引：Patel, Hasmukh S.; Patel, Sumeet J. Phosphorus, Sulfur and Silicon and the Related Elements, 2010 , vol. 185, # 8 p. 1632 - 1639

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被引用次数: 1

摘要

2-Hydroxy benzoic acid hydrazide (1) undergoes facile condensation with aromatic aldehydes to afford the corresponding 2-hydroxy benzoic acid arylidene hydrazides (2a–h) in good yields. Cyclocondensation of compounds 2a–h with thioglycolic acid yields 2- hydroxy-N (4-oxo-2-aryl-thiazolidin-3-yl)-benzamides (3a–h). These 3a–h compounds are for the reacted with benzaldehyde in the presence of sodium ethanolate affords, giving 2- ...