Syntheses and evaluation of fluorinated benzothiazole anilines as potential tracers for β-amyloid plaques in Alzheimer's disease

MQ Zheng, DZ Yin, JP Qiao, L Zhang…

文献索引：Zheng, Ming-Qiang; Yin, Duan-Zhi; Qiao, Jin-Ping; Zhang, Lan; Wang, Yong-Xian Journal of Fluorine Chemistry, 2008 , vol. 129, # 3 p. 210 - 216

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被引用次数: 20

摘要

[11C] 2-(4′-(Methylamino) phenyl)-6-hydroxybenzothiazole ([11C] PIB) is a most potential PET tracer for detecting the β-amyloid plaques in Alzheimer's disease. Here the syntheses of three fluorinated PIB, namely 2-(4′-(methylamino) phenyl)-6-fluoroethoxybenzothiazole (O- FEt-PIB), 2-(4′-(methylamino) phenyl)-6-fluoro-benzothiazole (FN-Me) and 2-(4′- (dimethylamino) phenyl)-6-fluorobenzo-thiazole (FN, N-Me), and the radiosynthesis of one ...