Development and evaluation of endothelin-A receptor (radio) ligands for positron emission tomography

K Michel, K Büther, MP Law, S Wagner, O Schober…

文献索引：Wagner, Stefan; Law, Marilyn P.; Riemann, Burkhard; Pike, Victor W.; Breyholz, Hans-Joerg; Hoeltke, Carsten; Faust, Andreas; Schober, Otmar; Schaefers, Michael; Kopka, Klaus Journal of Labelled Compounds and Radiopharmaceuticals, 2005 , vol. 48, # 10 p. 721 - 733 Title/Abstract Full Text View citing articles Show Details Wagner, Stefan; Law, Marilyn P.; Riemann, Burkhard; Pike, Victor W.; Breyholz, Hans-Joerg; Hoeltke, Garsten; Faust, Andreas; Renner, Christiane; Schober, Otmar; Schaefers, Michael; Kopka, Klaus Journal of Labelled Compounds and Radiopharmaceuticals, 2006 , vol. 49, # 2 p. 177 - 195

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被引用次数: 15

摘要

The expression and function of endothelin (ET) receptors are abnormal in cardiovascular diseases, tumor progression, and tumor metastasis. A previously reported promising radioligand for positron emission tomography (PET) based on the non-peptide ETA receptor antagonist PD 156707 showed specific binding to target receptors in the myocardium but high accumulation in bile and intestine, probably because of its high lipophilicity. In this ...