New Disulfide Route to 3-(1-Piperazinyl)-1, 2-benzisothiazole. Nucleus for Atypical Antipsychotic Drugs

SW Walinsky, DE Fox, JF Lambert…

文献索引：Organic Process Research and Development, , vol. 3, # 2 p. 126 - 130

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被引用次数: 10

摘要

... prepare 3-piperazinyl-1,2-benzisothiazoles 1 were not suitable for large-scale, commercial processes since the ... The new disulfide route represents a high-yielding, one-step process to 1, a nucleus for ... CH 2 Cl 2 −water (1:1), the layers were separated, and the organic layer was ...