Heterocycles

Synthesis of an orally active PAF antagonist of the N-[4-(3-pyridinyl) butyl] pentadienamide class

…, A Schwartz, S Wolff, PS Belica, P MADAN, P PATEL…

文献索引：Manchand, Percy S.; Schwartz, Alan; Wolff, Steven; Belica, Peter S.; Madan, Pradeep; et al. Heterocycles, 1993 , vol. 35, # 2 p. 1351 - 1369

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被引用次数: 10

摘要

Résumé/Abstract The PAF antagonist [R-(E, E)]-5-(4-methoxyphenyl)-N-[1-methyl-4-(3- pyridinyl) butyl]-2, 4-decadienamide (2) was synthesized from (S)-α-methyl-3- pyridinebutanol (14), which was obtained either from ethyl lactate or by enantioselective kinetic hydrolysis of its racemate using the lipase derived from Pseudomonaas cepacia (syn. P. fluorescens). Mesylation of 14, followed by azide displacement and hydrogenation, ...