Nitrocatechols versus nitrocatecholamines as novel competitive inhibitors of neuronal nitric oxide synthase: lack of the aminoethyl side chain determines loss of …
A Palumbo, A Napolitano, M d'Ischia
文献索引：Palumbo, Anna; Napolitano, Alessandra; D'Ischia, Marco Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 1 p. 13 - 16
6-Nitrocatecholamines were recently described as novel neuronal nitric oxide synthase inhibitors competing with both l-arginine and tetrahydrobiopterin (BH4). We report now that simple nitrocatechols are also competitive inhibitors, lacking however BH4-antagonizing properties. It is argued that 6-nitrocatecholamines interact with the l-arginine-and BH4- binding sites through the nitrocatechol and aminoethyl moieties, respectively.
