Tetrahedron letters

Asymmetric synthesis of RK-682 and its analogs, and evaluation of their protein phosphatase inhibitory activities

M Sodeoka, R Sampe, T Kagamizono, H Osada

文献索引：Sodeoka, Mikiko; Sampe, Ruriko; Kagamizono, Terumi; Osada, Hiroyuki Tetrahedron Letters, 1996 , vol. 37, # 48 p. 8775 - 8778

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被引用次数: 36

摘要

We report an asymmetric synthesis of a potent tyrosine phosphatase inhibitor, RK-682 and its analogs. The absolute stereochemistry of RK-682 was determined to be (R). The inhibitory activities of RK-682 and its analogs,(R)-1a,(S)-1a,(R)-1b and (R)-1c toward various protein phosphatases (VHR, cdc25A, cdc25B, and PP1) are also reported.